Premium
Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?—A [ 99m Tc]‐TRODAT‐1 SPECT study
Author(s) -
Shih Ming Chi,
Franco de Andrade Luiz Augusto,
Amaro Edson,
Felicio Andre Carvalho,
Ferraz Henrique Ballalai,
Wagner Jairo,
Hoexter Marcelo Queiroz,
Lin Li Fu,
Fu Ying Kai,
Mari Jair Jesus,
Tufik Sergio,
Bressan Rodrigo Affonseca
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21315
Subject(s) - dopamine transporter , parkinson's disease , dopamine , medicine , disease , central nervous system disease , psychology , endocrinology , dopaminergic
Early‐onset Parkinson's disease (EOPD) is distinct from the classic late‐onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [ 99m Tc]‐TRODAT‐1‐SPECT (INER‐Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 ± 0.12, BP = 0.44 ± 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor‐symptom worsening. © 2007 Movement Disorder Society