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Severe hypokinesis caused by paraneoplastic anti‐Ma2 encephalitis associated with bilateral intratubular germ‐cell neoplasm of the testes
Author(s) -
Matsumoto Lumine,
Yamamoto Tomotaka,
Higashihara Mana,
Sugimoto Izumi,
Kowa Hisatomo,
Shibahara Junji,
Nakamura Koichiro,
Shimizu Jun,
Ugawa Yoshikazu,
Goto Jun,
Dalmau Josep,
Tsuji Shoji
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21314
Subject(s) - medicine , neoplasm , pathology
We report a 40‐year‐old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma in situ ” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti‐Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti‐Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits. © 2006 Movement Disorder Society