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Mood stability during acute stimulator challenge in Parkinson's disease patients under long‐term treatment with subthalamic deep brain stimulation
Author(s) -
Berney Alexandre,
Panisset Michel,
Sadikot Abbas F.,
Ptito Alain,
Dagher Alain,
Fraraccio Maria,
Savard Ghislaine,
Pell Marc,
Benkelfat Chawki
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21245
Subject(s) - deep brain stimulation , mood , parkinson's disease , subthalamic nucleus , depression (economics) , anxiety , stimulation , psychology , medicine , disease , physical medicine and rehabilitation , psychiatry , neuroscience , economics , macroeconomics
Acute and chronic behavioral effects of subthalamic stimulation (STN‐DBS) for Parkinson's disease (PD) are reported in the literature. As the technique is relatively new, few systematic studies on the behavioral effects in long‐term treated patients are available. To further study the putative effects of STN‐DBS on mood and emotional processing, 15 consecutive PD patients under STN‐DBS for at least 1 year, were tested ON and OFF stimulation while on or off medication, with instruments sensitive to short‐term changes in mood and in emotional discrimination. After acute changes in experimental conditions, mood core dimensions (depression, elation, anxiety) and emotion discrimination processing remained remarkably stable, in the face of significant motor changes. Acute stimulator challenge in long‐term STN‐DBS–treated PD patients does not appear to provoke clinically relevant mood effects. © 2007 Movement Disorder Society