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LRRK2 G2019S founder haplotype in the Chinese population
Author(s) -
Tan EngKing,
Skipper Lisa,
Tan Louis,
Liu JianJun
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21206
Subject(s) - haplotype , lrrk2 , genetics , founder effect , mutation , biology , population , chinese population , gene , allele , medicine , genotype , environmental health
Abstract The G2019S mutation in the LRRK2 (leucine‐rich repeat kinase) gene appears very rarely in the Chinese population. Among Chinese subjects who were non‐G2019S carriers, we demonstrated the frequency of the LRRK2 G2019S founder haplotype (T‐254‐A‐G‐A‐154) in Parkinson's disease and controls to be 33% and 30%. This rate is similar to the frequency in European noncarriers, indirectly supporting the association of this haplotype with G2019S carriers. The haplotype is likely to be more ancient than the G2019S mutation because it is also found in a population with a very low carrier rate. © 2006 Movement Disorder Society