Premium
Autopsy‐proven Huntington's disease with 29 trinucleotide repeats
Author(s) -
Kenney Christopher,
Powell Suzanne,
Jankovic Joseph
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21195
Subject(s) - trinucleotide repeat expansion , huntington's disease , huntingtin , autopsy , huntingtin protein , disease , genetics , degenerative disease , medicine , biology , gene , pathology , allele
Huntington's disease (HD) is a neurodegenerative disorder associated with expansion of CAG trinucleotide repeats in the huntingtin gene. A minimum of 36 CAG repeats is usually reported in patients with clinical features of HD; 30 to 35 repeats represent an intermediate range. Here we report a 65‐year‐old male with autopsy‐proven HD and 29 CAG repeats. © 2006 Movement Disorder Society