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Striatal dopaminergic neurons are lost with Parkinson's disease progression
Author(s) -
Porritt Michelle J.,
Kingsbury Ann E.,
Hughes Andrew J.,
Howells David W.
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21129
Subject(s) - dopaminergic , striatum , parkinson's disease , neuroscience , disease , degenerative disease , medicine , basal ganglia , central nervous system disease , dopamine , psychology , central nervous system
Abstract Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (≤8 years), the number of dopaminergic neurons is approximately four times that in patients with long duration (≥16 years). The data suggest the possibility that the presence of large numbers of these striatal dopaminergic neurons may be harmful and may accelerate the disease process. Alternatively, these neurons may be lost to the disease process. © 2006 Movement Disorder Society