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Unilateral positive–negative myoclonus in Creutzfeldt–Jakob disease
Author(s) -
Ohnari Keiko,
Matsunaga Kaoru,
Uozumi Takenori,
Tamagawa Akira,
Hashimoto Tomoko,
Tsuji Sadatoshi
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21078
Subject(s) - myoclonus , medicine , creutzfeldt jakob syndrome , degenerative disease , central nervous system disease , disease , pathology , psychiatry , prion protein
Abstract We report a patient with Creutzfeldt–Jakob disease who presented asymmetric myoclonus. Positive–negative myoclonus was seen only in the right extremities in association with periodic synchronous discharges (PSDs) on the electroencephalogram, although pure positive myoclonus was rarely seen in the left extremities, independently in PSDs. The duration of the silent period recorded in the right‐hand muscle produced by transcranial magnetic stimulation was much longer than that in the left‐hand muscle or that in normal subjects. Brain MRI diffusion‐weighted images showed signal hyperintensities in the putamen and cerebral cortex, including the motor cortex, predominantly on the left side. © 2006 Movement Disorder Society

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