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123 I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism
Author(s) -
Gaig Carles,
Martí Maria José,
Tolosa Eduardo,
Valldeoriola Francesc,
Paredes Pilar,
Lomeña Francisco Juan,
Nakamae Fernando
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21062
Subject(s) - parkinsonism , psychogenic disease , movement disorders , dopamine transporter , medicine , essential tremor , parkin , emission computed tomography , positron emission tomography , degenerative disease , spect imaging , parkinson's disease , single photon emission computed tomography , central nervous system disease , psychology , neuroscience , nuclear medicine , disease , radiology , pathology , dopamine , dopaminergic
Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123 I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123 I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123 I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society