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Alzheimer's disease presenting as corticobasal syndrome
Author(s) -
Chand Pratap,
Grafman Jordan,
Dickson Dennis,
Ishizawa Keisuke,
Litvan Irene
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21055
Subject(s) - neuropathology , apraxia , dystonia , parkinsonism , corticobasal degeneration , psychology , neuropsychology , myoclonus , neuroscience , degenerative disease , disease , progressive supranuclear palsy , medicine , central nervous system disease , pathology , aphasia , cognition
A 60‐year‐old man presented with slowly progressive left hemi‐Parkinsonism, left hand apraxia, myoclonus, dystonia, visuospatial disturbances, and alien limb phenomenon, resembling corticobasal syndrome. Eight years later, neuropathology revealed features of Alzheimer's disease, with asymmetrical (right more than left) cortical tau burden with image analysis. The videotaped clinical features, neuropsychological aspects, and neuropathological correlates are presented and discussed. © 2006 Movement Disorder Society