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Impact of bilateral pallidal stimulation on DYT1‐generalized dystonia in Japanese patients
Author(s) -
Goto Satoshi,
Yamada Kazumichi,
Shimazu Hideki,
Murase Nagako,
Matsuzaki Kazuhito,
Tamura Tetsuya,
Nagahiro Shinji,
Kuratsu JunIchi,
Kaji Ryuji
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21021
Subject(s) - dystonia , deep brain stimulation , globus pallidus , stimulation , medicine , movement disorders , physical medicine and rehabilitation , neuroscience , psychology , basal ganglia , parkinson's disease , central nervous system , disease
Early‐onset generalized dystonia attributable to a DYT1 gene mutation is a hyperkinetic movement disorder that responds poorly to pharmacotherapy. In this video brief, we show that continuous bilateral stimulation of the globus pallidus internus produced sustained and marked improvements in the motor symptoms and functional disabilities of Japanese patients with DYT1‐generalized dystonia. © 2006 Movement Disorder Society