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NR4A2 genetic variation in sporadic Parkinson's disease: A genewide approach
Author(s) -
Healy Daniel G.,
AbouSleiman Patrick M.,
Ahmadi Kourosh R.,
Gandhi Sonia,
Muqit Miratul M.,
Bhatia Kailash P.,
Quinn Niall P.,
Lees Andrew J.,
Holton Janice L.,
Revesz Tamas,
Wood Nicholas W.
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21018
Subject(s) - haplotype , parkinson's disease , disease , genetic variation , genetics , population , degenerative disease , biology , gene , medicine , allele , environmental health
The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype‐tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population. © 2006 Movement Disorder Society