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Chemical exposures and Parkinson's disease: A population‐based case–control study
Author(s) -
Frigerio Roberta,
Sanft Kevin R.,
Grossardt Brandon R.,
Peterson Brett J.,
Elbaz Alexis,
Bower James H.,
Ahlskog J. Eric,
De Andrade Mariza,
Maraganore Demetrius M.,
Rocca Walter A.
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21009
Subject(s) - odds ratio , confidence interval , case control study , pesticide , population , medicine , disease , epidemiology , demography , essential tremor , environmental health , gerontology , biology , psychiatry , ecology , sociology
The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (± 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1–5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population‐based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women. © 2006 Movement Disorder Society