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Dopamine transporters, D2 receptors, and glucose metabolism in corticobasal degeneration
Author(s) -
Klaffke Stefanie,
Kuhn Andrea A.,
Plotkin Michail,
Amthauer Holger,
Harnack Daniel,
Felix Roland,
Kupsch Andreas
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21004
Subject(s) - corticobasal degeneration , dopaminergic , dopamine receptor d2 , dopamine transporter , dopamine , dopamine plasma membrane transport proteins , medicine , endocrinology , dopamine receptor , postsynaptic potential , neuroscience , receptor , chemistry , psychology , progressive supranuclear palsy , disease
Alterations in presynaptic and postsynaptic dopaminergic system and cerebral glucose metabolism in corticobasal degeneration (CBD) were assessed to evaluate the potential usefulness of different imaging methods for CBD. 123 I‐FP‐CIT/ 123 I‐β‐CIT SPECT and 123 I‐IBZM SPECT as well as 18 F‐FDG PET were performed in eight CBD patients. Decreased presynaptic dopamine transporter binding was found in all CBD patients while D2 receptor binding was reduced in only one patient. 18 F‐FDG PET displayed a contralateral hypometabolism in cortical and subcortical areas in seven out of eight patients. Our results demonstrate that glucose metabolism and DAT are reduced, while D2 receptors may be frequently preserved in CBD. © 2006 Movement Disorder Society