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Botulinum toxin treatment of facial myoclonus in suspected Rasmussen encephalitis
Author(s) -
Browner Nina,
Azher Shaheda N.,
Jankovic Joseph
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20991
Subject(s) - basal ganglia , myoclonus , botulinum toxin , positron emission tomography , medicine , magnetic resonance imaging , atrophy , hemiparesis , thalamus , myoclonic jerk , spastic , psychology , anesthesia , neuroscience , pathology , central nervous system , physical medicine and rehabilitation , radiology , lesion , cerebral palsy
Abstract Patients with Rasmussen encephalitis (RE) may develop a variety of involuntary movements. We report a 26‐year‐old woman who presented with a 3‐year history of progressive, continuous myoclonus of the left side of the face and left arm as well as left spastic hemiparesis. Magnetic resonance imaging of the brain showed right hemisphere and basal ganglia atrophy, and 24‐hour electroencephalogram demonstrated diffuse slowing with random sharp waves in both hemispheres. An 18‐fluoro‐deoxy‐glucose positron emission tomography scan indicated hypometabolism of the right cerebral hemisphere, including basal ganglia and thalamus. We successfully treated her myoclonus with injections of botulinum toxin A into the left zygomaticus muscle. © 2006 Movement Disorder Society