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Holmes tremor: Application of modern neuroimaging techniques
Author(s) -
Paviour Dominic C.,
Jäger H. Rolf,
Wilkinson Leonora,
Jahanshahi Marjan,
Lees Andrew J.
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20981
Subject(s) - midbrain , neuroimaging , brainstem , ataxia , neuroscience , lesion , essential tremor , movement disorders , psychology , medicine , physical medicine and rehabilitation , central nervous system , disease , pathology , psychiatry
Holmes tremor has a characteristic rest, intention, and postural component. The syndrome arises as a consequence of a lesion in the upper brainstem and cerebral peduncles, which, it is postulated, interrupts the cerebello‐rubrothalamic pathway. Ataxia, ophthalmoplegia, and bradykinesia are associated features. We present a case of Holmes tremor secondary to a midbrain cavernoma. Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello‐rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur. © 2006 Movement Disorder Society