Glutamate release inhibition ineffective in Levodopa‐induced motor complications | Zendy

BaraJimenez William | Zendy; Dimitrova Tzvetelina D. | Zendy; Sherzai Abdullah | Zendy; Aksu Murat | Zendy; Chase Thomas N. | Zendy

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Glutamate release inhibition ineffective in Levodopa‐induced motor complications

Author(s) -

BaraJimenez William,

Dimitrova Tzvetelina D.,

Sherzai Abdullah,

Aksu Murat,

Chase Thomas N.

Publication year - 2006

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.20976

Subject(s) - glutamatergic , levodopa , glutamate receptor , riluzole , parkinson's disease , medicine , dyskinesia , neuroscience , neurotransmission , pharmacology , anesthesia , psychology , disease , receptor

Reported benefits of various glutamatergic receptor antagonists in Parkinson's disease (PD) prompted an evaluation of the antidyskinetic effect of a putative glutamate release inhibitor in 15 moderately advanced patients. In a 3‐week, double‐blind, proof‐of‐concept study, riluzole (200 mg/day) failed to alter parkinsonian or levodopa‐induced motor complication severity. Opposing effects of a generalized inhibition of glutamate‐mediated synaptic transmission may limit the usefulness of this approach to treat PD. © 2006 Movement Disorder Society

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