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Atypical movement disorders in antiphospholipid syndrome
Author(s) -
Martino Davide,
Chew NeeKong,
Mir Pablo,
Edwards Mark J.,
Quinn Niall P.,
Bhatia Kailash P.
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20842
Subject(s) - chorea , movement disorders , parkinsonism , myoclonus , antiphospholipid syndrome , tics , medicine , dyskinesia , pediatrics , neurological disorder , dystonia , disease , central nervous system disease , psychiatry , parkinson's disease , thrombosis
Movement disorders have only rarely been reported in association with antiphospholipid syndrome (APS). In such cases, chorea is the most common disorder observed, with occasional reports of hemidystonia, Parkinsonism, and hemiballism. We report here on 3 cases of APS (3 women ages 16, 46, and 56 years) who presented with movement disorders, including tics, tremor, myoclonus, and a corticobasal syndrome, never or rarely reported in association with this disease. Mild executive dysfunction was observed in all 3 patients. We also report the successful treatment of two of these patients with mild oral anticoagulation (INR 2–3). Movement disorders in APS seem more clinically heterogeneous than previously thought. Oral anticoagulation should be considered in the treatment of movement disorders associated with APS. © 2006 Movement Disorder Society