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Recessive Parkinson's disease
Author(s) -
Kubo ShinIchiro,
Hattori Nobutaka,
Mizuno Yoshikuni
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20841
Subject(s) - substantia nigra , parkin , pars compacta , pink1 , parkinson's disease , pathogenesis , disease , dopaminergic , genetics , degenerative disease , proteasome , biology , lrrk2 , neuroscience , oxidative stress , medicine , pathology , central nervous system disease , dopamine , immunology , endocrinology
Parkinson's disease (PD) is a progressive neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains unclear, it is now clear that genetic factors contribute to the pathogenesis of the disease. Recently, several causative genes have been identified in monogenic forms of PD. Accumulating evidence indicates that their gene products play important roles in mitochondrial function, oxidative stress response, and the ubiquitin–proteasome system, which are also implicated in sporadic PD, suggesting that these gene products share a common pathway to nigral degeneration in both familial and sporadic PD. Here, we review recent advances in knowledge about genes associated with recessive PD, including parkin , PINK1 , and DJ‐1 . © 2006 Movement Disorder Society