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Deep brain stimulation in Tourette's syndrome: Two targets?
Author(s) -
Ackermans Linda,
Temel Yasin,
Cath Danielle,
van der Linden Chris,
Bruggeman Richard,
Kleijer Mariska,
Nederveen Pieter,
Schruers Koen,
Colle Henry,
Tijssen Marina A.J.,
VisserVandewalle Veerle
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20816
Subject(s) - deep brain stimulation , thalamus , tics , tourette syndrome , globus pallidus , thalamic stimulator , stimulation , psychology , medicine , neuroscience , subthalamic nucleus , anesthesia , basal ganglia , psychiatry , parkinson's disease , central nervous system , disease
In this report, we describe the effects of bilateral thalamic stimulation in one patient and of bilateral pallidal stimulation in another patient. Both patients suffered from intractable Tourette’s syndrome (TS). Any conservative treatment had failed or had been stopped because of unbearable side effects in the 2 patients. In both cases, there was no comorbidity except for associated behavioral symptoms (compulsions). Electrodes were implanted at the level of the medial part of the thalamus (centromedian nucleus, the substantia periventricularis, and the nucleus ventro‐oralis internus) in one patient and in the posteroventral part of the globus pallidus internus (GPi) in the other patient. In both cases, deep brain stimulation (DBS) resulted in a substantial reduction of tics and compulsions. These data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable TS. © 2006 Movement Disorder Society