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Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease
Author(s) -
Fung HonChung,
Chen ChiungMei,
Hardy John,
Hernandez Dena,
Singleton Andrew,
Wu YihRu
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20814
Subject(s) - lrrk2 , cohort , parkinson's disease , medicine , disease , mutation , central nervous system disease , degenerative disease , cohort study , pediatrics , genetics , biology , gene
Mutations in the leucine‐rich repeat kinase 2 ( LRRK2 ) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. © 2006 Movement Disorder Society