Lack of G2019S  LRRK2  mutation in a cohort of Taiwanese with sporadic Parkinson's disease | Zendy

Fung HonChung | Zendy; Chen ChiungMei | Zendy; Hardy John | Zendy; Hernandez Dena | Zendy; Singleton Andrew | Zendy; Wu YihRu | Zendy

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Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease

Author(s) -

Fung HonChung,

Chen ChiungMei,

Hardy John,

Hernandez Dena,

Singleton Andrew,

Wu YihRu

Publication year - 2006

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.20814

Subject(s) - lrrk2 , cohort , parkinson's disease , medicine , disease , mutation , central nervous system disease , degenerative disease , cohort study , pediatrics , genetics , biology , gene

Mutations in the leucine‐rich repeat kinase 2 ( LRRK2 ) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. © 2006 Movement Disorder Society

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