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Hereditary spastic paraplegia associated with dopa‐responsive parkinsonism
Author(s) -
Micheli Federico,
Cersósimo María Graciela,
Zúñiga Ramírez Carlos
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20800
Subject(s) - parkinsonism , paraplegia , hereditary spastic paraplegia , spastic , medicine , physical medicine and rehabilitation , neurological disorder , degenerative disease , central nervous system disease , neuroscience , physical therapy , psychology , surgery , spinal cord , psychiatry , biology , pathology , cerebral palsy , disease , biochemistry , gene , phenotype
A 47‐year‐old patient with hereditary spastic paraplegia and parkinsonian features is reported. Treatment with levodopa led to marked improvement in his neurological status and quality of life. However, several years later he developed motor fluctuations and dyskinesias. The latter promptly remitted with amantadine treatment. © 2006 Movement Disorder Society