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Sensitivity and specificity of a self‐administered questionnaire for familial screening of adult‐onset dystonia
Author(s) -
Aniello Maria Stella,
Martino Davide,
Masi Gianluca,
Livrea Paolo,
Defazio Giovanni
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20760
Subject(s) - dystonia , context (archaeology) , medicine , pediatrics , physical therapy , psychology , psychiatry , biology , paleontology
We developed a self‐administered questionnaire for screening the most common adult‐onset dystonias. It was tested in 90 first‐degree relatives of 22 adult‐onset dystonia patients, yielding 79% sensitivity and 94% specificity. Simulation of a case‐finding procedure based on serial application of the questionnaire and clinical examination of both subjects screening positive and subjects screening negative who had < 8 years of schooling increased sensitivity to 95% and specificity to 100%. This questionnaire may be an important screening resource for familial aggregation studies to be used in the context of a complex case‐finding procedure. © 2005 Movement Disorder Society