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Acute reversible parkinsonism in Epstein–Bbarr virus–related encephalitis lethargica‐like illness
Author(s) -
Dimova Petia S.,
Bojinova Veneta,
Georgiev Dimitar,
Milanov Ivan
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20742
Subject(s) - parkinsonism , dysphagia , encephalitis , medicine , magnetic resonance imaging , vomiting , pathology , viral encephalitis , surgery , radiology , virus , virology , disease
A 10‐year‐old boy presented with fever, headache, vomiting, and hypersomnolence. An akinetic–rigid syndrome with tremor, dysphagia, dysphonia, and sialorrhea, as well as pyramidal signs, developed. Slightly elevated protein content was found in the cerebrospinal fluid and serological investigations were suggestive of a primary Epstein–Barr virus infection. Magnetic resonance imaging (MRI) showed massive bilateral hyperintense striatal and punctiform periventricular lesions. After 2‐month treatment with steroids and antiparkinsonian drugs, all features resolved without sequelae. Control MRI demonstrated only minimal residual lesions in both putamina. Strongly resembling the encephalitis lethargica‐like syndrome, this case is an unusual presentation of parainfectious acute disseminated encephalitis. © 2005 Movement Disorder Society