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REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease
Author(s) -
Sinforiani Elena,
Zangaglia Roberta,
Manni Raffaele,
Cristina Silvano,
Marchioni Enrico,
Nappi Giuseppe,
Mancini Francesca,
Pacchetti Claudio
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20719
Subject(s) - psychology , rem sleep behavior disorder , neuropsychology , cognition , audiology , cognitive disorder , rapid eye movement sleep , parkinson's disease , cognitive impairment , psychiatry , disease , medicine , polysomnography , electroencephalography
The objective of this study was to evaluate the relationship between REM sleep behavior disorder (RBD), hallucinations, and cognitive impairment in Parkinson's disease (PD). One hundred and ten PD patients, divided into three groups (without RBD or hallucinations; with RBD but no hallucinations; with RBD and hallucinations), were submitted to neuropsychological evaluation. The group without RBD and hallucinations showed normal neuropsychological tests when compared to normal controls. The group with hallucinations was characterized by a more severe cognitive impairment affecting both short‐ and long‐term memory, logical abilities, and frontal functions, while the RBD‐only group presented frontal impairment. The hypothesis that RBD in PD can be considered a risk factor not only of the hallucinations but also of more severe and diffuse cognitive abnormalities needs to be strengthened through a longitudinal evaluation. © 2005 Movement Disorder Society