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Global versus factor‐related impression of severity in Parkinson's disease: A new clinimetric index (CISI‐PD)
Author(s) -
MartínezMartín Pablo,
Forjaz M. João,
Cubo Esther,
Frades Belén,
de Pedro Cuesta Jesús
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20697
Subject(s) - clinical global impression , parkinson's disease , rating scale , psychology , physical therapy , correlation , severity of illness , convergent validity , physical medicine and rehabilitation , clinical psychology , psychometrics , disease , internal consistency , medicine , psychiatry , developmental psychology , pathology , alternative medicine , geometry , mathematics , placebo
Abstract In Parkinson's disease (PD), the Clinical Global Impression of Severity (CGIS) is often used as an additional outcome in clinical trials. It is hypothesized that this measure summarizes clinical assessment and is mainly influenced by the rating of four domains, namely, motor signs, disability, motor complications, and cognitive impairment. Ratings of these four factors were combined to form a new Clinical Impression of Severity Index for Parkinson's Disease (CISI‐PD). A sample of 150 PD patients was evaluated using the following scales: Hoehn and Yahr staging, Schwab and England scale, Unified Parkinson's Disease Rating Scale, Scales for Outcomes in Parkinson's Disease–Motor Scale, CGIS, and CISI‐PD. The results show that the CGIS is closely related to the above‐mentioned measures (r = 0.49–0.89). CISI‐PD correlation with these scales was very similar (r = 0.55–0.91), to the extent that the difference between corresponding coefficients was systematically less than 0.10. A multiple regression model showed that 92% of the CIGS variance was explained by the four CISI‐PD items. Finally, the CISI‐PD displayed adequate psychometric properties, with satisfactory internal consistency (α = 0.90) and convergent (r > 0.75) and known‐groups validity. The CISI‐PD is a valid and reliable measure that expands the information obtained via the CGIS. © 2005 Movement Disorder Society