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Co‐occurrence of restless legs syndrome and Parkin mutations in two families
Author(s) -
Adel Susanna,
Djarmati Ana,
Kabakci Kemal,
Pichler Irene,
Eskelson Cordula,
Lohnau Thora,
Kock Norman,
Hagenah Johann,
Hedrich Katja,
Schwinger Eberhard,
Kramer Patricia L.,
Pramstaller Peter P.,
Klein Christine
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20690
Subject(s) - parkin , restless legs syndrome , genetics , mutation , degenerative disease , parkinson's disease , disease , genetic linkage , medicine , psychology , biology , neurology , psychiatry , gene
Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS. © 2005 Movement Disorder Society