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Comorbid conditions associated with Parkinson's disease: A population‐based study
Author(s) -
Leibson Cynthia L.,
Maraganore Demetrius M.,
Bower James H.,
Ransom Jeanine E.,
O'Brien Peter C.,
Rocca Walter A.
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20685
Subject(s) - parkinson's disease , medicine , disease , population , degenerative disease , central nervous system disease , comorbidity , physical medicine and rehabilitation , psychiatry , psychology , environmental health
The burden of comorbidity in Parkinson's disease (PD) remains unclear. All Olmsted County, Minnesota, residents with incident PD in 1976–1995 (n = 197) plus one age‐ and sex‐matched non‐PD referent subject per case were followed for all clinical diagnoses from 5 years before through 15 years after index (i.e., year of PD onset for each case and same year for the referent subject). Both members of a case–referent pair were censored at death or emigration of either member to ensure equivalent follow‐up. Cases and referent subjects were compared for summary comorbidity (Charlson index) and for the likelihood of having one or more diagnoses within each International Classification of Diseases chapter/subchapter. Before index, the groups were similar for all comparisons. After index, cases had a higher likelihood of diagnoses within the chapters “Mental Disorders” and “Diseases of the Genitourinary System,” and within the subchapters “Organic Psychotic Conditions,” “Other Psychoses,” “Neurotic/Personality/Other Nonpsychotic Disorders,” “Hereditary/Degenerative Diseases of Central Nervous System,” “Symptoms,” “Other Diseases of Digestive System,” “Other Diseases of Urinary System,” “Diseases of Veins/Lymphatics/Other Circulatory System Diseases,” “Fractures of Lower Limb,” “Other Diseases of Skin/Subcutaneous Tissue,” “Osteopathies/Chrondropathies/Acquired Musculoskeletal Deformities,” and “Pneumonia and Influenza.” The excess morbidity and mortality observed for persons with PD are consistent with recognized PD sequelae. © 2005 Movement Disorder Society