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Deep brain stimulation to treat hyperkinetic symptoms of cockayne syndrome
Author(s) -
Hebb Matthew O.,
Gaudet Paula,
Mendez Ivar
Publication year - 2006
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20665
Subject(s) - cockayne syndrome , deep brain stimulation , thalamus , stimulation , medicine , movement disorders , neuroscience , thalamic stimulator , neurological disorder , anesthesia , psychology , physical medicine and rehabilitation , central nervous system disease , parkinson's disease , biology , disease , biochemistry , nucleotide excision repair , dna repair , gene
Abstract Cockayne syndrome manifests a spectrum of neurological dysfunction that includes medically intractable movement disorders. Deep brain stimulation has not been well studied in such rare neurodegenerative conditions. In this case, stimulation of the ventral intermediate nucleus of the thalamus was used to manage severe motor symptoms in a young man with Cockayne syndrome. There was a marked and progressive response to thalamic stimulation within weeks of surgery. These results suggest that patients with Cockayne syndrome should be considered for deep brain stimulation to treat refractory movement disorders. © 2005 Movement Disorder Society