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Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe
Author(s) -
Champy Pierre,
Melot Alice,
Guérineau Eng Vincent,
Gleye Christophe,
Fall Djibril,
Höglinger Gunter U.,
Ruberg Merle,
Lannuzel Annie,
Laprévote Olivier,
Laurens Alain,
Hocquemiller Reynald
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20632
Subject(s) - annona muricata , acetogenin , decoction , nectar , annonaceae , traditional medicine , chemistry , sepal , aroma , biology , botany , medicine , food science , stamen , pollen
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata , in extracts of fruit and leaves by matrix‐assisted laser desorption‐ionization mass spectrometry. An average fruit is estimated to contain about 15 mg of annonacin, a can of commercial nectar 36 mg, and a cup of infusion or decoction 140 μg. As an indication of its potential toxicity, an adult who consumes one fruit or can of nectar a day is estimated to ingest over 1 year the amount of annonacin that induced brain lesions in rats receiving purified annonacin by intravenous infusion. © 2005 Movement Disorder Society