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Alpha‐synuclein immunohistochemistry in two cases of co‐occurring idiopathic Parkinson's disease and motor neuron disease
Author(s) -
Klos Kevin J.,
Josephs Keith A.,
Parisi Joseph E.,
Dickson Dennis W.
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20604
Subject(s) - alpha synuclein , parkinson's disease , motor neuron , disease , medicine , immunohistochemistry , degenerative disease , central nervous system disease , pathology , neuroscience , psychology
We report on two cases of sporadic idiopathic Parkinson's disease with motor neuron disease co‐occurring in the same individuals. Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. We compared our two cases to all previously published pathological cases of combined LBD and motor neuron degeneration. © 2005 Movement Disorder Society