Premium
Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ ‐ 1 (T497C) genes in familial Parkinson's disease from the Gene PD study
Author(s) -
Karamohamed Samer,
Golbe L.I.,
Mark M.H.,
Lazzarini A.M.,
Suchowersky O.,
Labelle N.,
Guttman Mark,
Currie L.J.,
Wooten G.F.,
Stacy M.,
SaintHilaire M.,
Feldman R.G.,
Liu J.,
Shoemaker C.M.,
Wilk J.B.,
DeStefano A.L.,
Latourelle J.C.,
Xu G.,
Watts R.,
Growdon J.,
Lew M.,
Waters C.,
Vieregge P.,
Pramstaller P.P.,
Klein C.,
Racette B.A.,
Perlmutter J.S.,
Parsian A.,
Singer Carlos,
Montgomery E.,
Baker K.,
Gusella J.F.,
Herbert A.,
Myers R.H.
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20515
Subject(s) - parkinson's disease , proband , genetics , gene , disease , biology , medicine , mutation
Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA , NR4A2 , and DJ ‐ 1 genes in 292 cases of familial Parkinson's disease from the Gene PD study. None of the variants were found in the Gene PD families. Our results suggest that other variants or genes account for the familial risk of PD within the Gene PD study. © 2005 Movement Disorder Society