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Genetic testing in Parkinson's disease
Author(s) -
McInerneyLeo Aideen
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20509
Subject(s) - government (linguistics) , library science , citation , gerontology , public health , psychology , medicine , computer science , pathology , philosophy , linguistics
Since my colleagues and I submitted a manuscript on the complexities of genetic testing in Parkinson's disease (PD),1 an important gene discovery has been made. The gene located at the PARK8 locus (12q), which was initially discovered in a Japanese family,2 has been identified. At the end of 2004, two research groups independently isolated the gene LRRK2 and recognized seven missense mutations in autosomal dominant families from England, Spain, Germany, and Canada.3, 4..