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Pallidal stimulation reduces treatment‐induced dyskinesias in “minimal‐change” multiple system atrophy
Author(s) -
Huang Yue,
Garrick Raymond,
Cook Raymond,
O'Sullivan Dudley,
Morris John,
Halliday Glenda M.
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20497
Subject(s) - parkinsonism , dyskinesia , levodopa , deep brain stimulation , atrophy , progressive supranuclear palsy , stimulation , degenerative disease , medicine , parkinson's disease , neuroscience , psychology , central nervous system disease , anesthesia , disease
Deep brain stimulation therapy is increasingly gaining acceptance in the management of levodopa‐induced dyskinesia and fluctuations in idiopathic Parkinson's disease. It is generally not recommended for the other forms of parkinsonism such as progressive supranuclear palsy or multiple system atrophy where the response to levodopa is usually poor and disease progression more rapid, making any benefit short‐lived. Here, we present an autopsy‐confirmed case of “minimal‐change” multiple system atrophy in whom pallidal stimulation surgery was effective in abolishing severe levodopa‐induced dyskinesia. © 2005 Movement Disorder Society