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Brain‐derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy
Author(s) -
Nishimura Masataka,
Kuno Sadako,
Kaji Ryuji,
Kawakami Hideshi
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20491
Subject(s) - atrophy , degenerative disease , brain derived neurotrophic factor , parkinson's disease , alzheimer's disease , neurotrophic factors , disease , genotype , polymorphism (computer science) , medicine , central nervous system disease , psychology , biology , gene , genetics , receptor
We studied two genetic polymorphisms (240C/T and 480G/A) of the brain‐derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD. © 2005 Movement Disorder Society