Hemiparkinsonism and levodopa‐induced dyskinesias after focal nigral lesion | Zendy

Růžička Evžen | Zendy; Urgošík Dušan | Zendy; Jech Robert | Zendy; Roth Jan | Zendy; Vymazal Josef | Zendy; Mečíř Petr | Zendy; Vladyka Vilibald | Zendy

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Hemiparkinsonism and levodopa‐induced dyskinesias after focal nigral lesion

Author(s) -

Růžička Evžen,

Urgošík Dušan,

Jech Robert,

Roth Jan,

Vymazal Josef,

Mečíř Petr,

Vladyka Vilibald

Publication year - 2005

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.20453

Subject(s) - parkinsonism , thalamotomy , levodopa , substantia nigra , lesion , medicine , dopaminergic , stereotactic surgery , extinction (optical mineralogy) , nigrostriatal pathway , movement disorders , parkinson's disease , dyskinesia , neuroscience , psychology , surgery , dopamine , disease , deep brain stimulation , pathology , physics , optics

We present a patient with tremor‐dominant hemiparkinsonism after a focal lesion to the substantia nigra. An excellent response to levodopa was complicated by rapid development of motor fluctuations and disabling dyskinesias. Stereotactic thalamotomy resulted in a persistent extinction of parkinsonism and of dyskinesias along with stopping dopaminergic treatment. © 2005 Movement Disorder Society

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