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Non‐movement disorder heralds symptoms of Machado‐Joseph disease years before ataxia
Author(s) -
D'Abreu Anelyssa,
Friedman Joseph,
Coskun Jim
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20419
Subject(s) - machado–joseph disease , ataxia , gait ataxia , movement disorders , abnormality , neurological disorder , disease , pediatrics , gait , degenerative disease , medicine , ataxic gait , psychology , family history , central nervous system disease , physical medicine and rehabilitation , psychiatry , neuroscience , spinocerebellar ataxia
Abstract We describe three patients with the Machado‐Joseph disease (MJD) genetic abnormality who had non‐movement disorder neurological symptoms or signs that preceded the gait ataxia by several years. This implies that some clinical manifestations other than ataxia may be considered part of the herald symptoms of MJD, especially in the setting of a positive family history. © 2005 Movement Disorder Society