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Alpha‐synuclein mRNA expression in sporadic Parkinson's disease
Author(s) -
Tan EngKing,
Chandran Van R.,
FookChong Stephanie,
Shen Hui,
Yew Kenneth,
Teoh MeiLin,
Yuen Yih,
Zhao Yi
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20391
Subject(s) - alpha synuclein , gene expression , messenger rna , parkinson's disease , confounding , alpha (finance) , biology , medicine , gene , epigenetics , real time polymerase chain reaction , microbiology and biotechnology , endocrinology , disease , genetics , clinical psychology , construct validity , psychometrics
Abstract The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society