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Investigation of genes coding for inflammatory components in Parkinson's disease
Author(s) -
Håkansson Anna,
Westberg Lars,
Nilsson Staffan,
Buervenich Silvia,
Carmine Andrea,
Holmberg Björn,
Sydow Olof,
Olson Lars,
Johnels Bo,
Eriksson Elias,
Nissbrandt Hans
Publication year - 2005
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20378
Subject(s) - single nucleotide polymorphism , allele , snp , biology , genetics , pathogenesis , parkinson's disease , disease , gene , genotype , immunology , medicine
Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon‐γ (IFN‐γ; T874A in intron 1), interferon‐γ receptor 2 (IFN‐γ R2; Gln64Arg), interleukin‐10 (IL‐10; G1082A in the promoter region), platelet‐activating factor acetylhydrolase (PAF‐AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM‐1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL‐10 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A‐alleles ( P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5‐year delayed age of onset of the disease for individuals having two G‐alleles compared with individuals having two A‐alleles. The results indicate that the IL‐10 G1082A SNP could possibly be related to the age of onset of PD. © 2005 Movement Disorder Society