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Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”
Author(s) -
Rissling Ida,
Geller Frank,
Bandmann Oliver,
StiasnyKolster Karim,
Körner Yvonne,
Meindorfner Charlotte,
Krüger HansPeter,
Oertel Wolfgang H.,
Möller J. Carsten
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20245
Subject(s) - parkinson's disease , dopamine , dopamine receptor , medicine , sleep (system call) , dopamine receptor d3 , neuroscience , disease , psychology , psychiatry , computer science , operating system
Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society