Effects of rivastigmine on motor and cognitive impairment in Huntington's disease | Zendy

de Tommaso Marina | Zendy; Specchio Nicola | Zendy; Sciruicchio Vittorio | Zendy; Difruscolo Olimpia | Zendy; Specchio Luigi Maria | Zendy

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Effects of rivastigmine on motor and cognitive impairment in Huntington's disease

Author(s) -

de Tommaso Marina,

Specchio Nicola,

Sciruicchio Vittorio,

Difruscolo Olimpia,

Specchio Luigi Maria

Publication year - 2004

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.20235

Subject(s) - rivastigmine , huntington's disease , cognitive impairment , disease , medicine , cognition , degenerative disease , physical medicine and rehabilitation , motor symptoms , psychology , central nervous system disease , parkinson's disease , audiology , neuroscience , dementia , donepezil

To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open‐label, randomized, controlled study. Twenty‐one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no‐treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration. © 2004 Movement Disorder Society

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