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Effects of rivastigmine on motor and cognitive impairment in Huntington's disease
Author(s) -
de Tommaso Marina,
Specchio Nicola,
Sciruicchio Vittorio,
Difruscolo Olimpia,
Specchio Luigi Maria
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20235
Subject(s) - rivastigmine , huntington's disease , cognitive impairment , disease , medicine , cognition , degenerative disease , physical medicine and rehabilitation , motor symptoms , psychology , central nervous system disease , parkinson's disease , audiology , neuroscience , dementia , donepezil
To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open‐label, randomized, controlled study. Twenty‐one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no‐treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration. © 2004 Movement Disorder Society