Premium
Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis
Author(s) -
Vermes Istvan,
Jansen Steur Ernst N.H.,
Jirikowski Gustav F.,
Haanen Clemens
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20197
Subject(s) - tissue transglutaminase , cerebrospinal fluid , apoptosis , parkinson's disease , programmed cell death , pathology , disease , cell , medicine , biology , biochemistry , enzyme
Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD. © 2004 Movement Disorder Society