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Reversible parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency
Author(s) -
Heales Simon,
Crawley Francesca,
Rudge Peter
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20158
Subject(s) - parkinsonism , tetrahydrobiopterin , heroin , inhalation , encephalopathy , dopamine , medicine , anesthesia , neuroscience , psychology , psychiatry , drug , nitric oxide , nitric oxide synthase , disease
A patient who inhaled heroin vapour (chasing the dragon), resulting in temporary parkinsonism, is described. A reversible deficiency of tetrahydrobiopterin, causing altered dopamine metabolism, is demonstrated as the metabolic basis of this aspect of the encephalopathy. © 2004 Movement Disorder Society
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