Adrafinil‐induced orofacial dyskinesia | Zendy

Thobois Stéphane | Zendy; Xie Jing | Zendy; Mollion Helena | Zendy; Benatru Isabelle | Zendy; Broussolle Emmanuel | Zendy

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Adrafinil‐induced orofacial dyskinesia

Author(s) -

Thobois Stéphane,

Xie Jing,

Mollion Helena,

Benatru Isabelle,

Broussolle Emmanuel

Publication year - 2004

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.20154

Subject(s) - tetrabenazine , modafinil , dyskinesia , vigilance (psychology) , tardive dyskinesia , medicine , dopaminergic , anesthesia , psychology , neuroscience , pharmacology , dopamine , psychiatry , parkinson's disease , schizophrenia (object oriented programming) , disease

We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4‐month period. They were secondly dramatically improved by tetrabenazine, a presynaptic dopaminergic depleting drug which was introduced after the 4‐month adrafinil‐free period. © 2004 Movement Disorder Society

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