Premium
Adrafinil‐induced orofacial dyskinesia
Author(s) -
Thobois Stéphane,
Xie Jing,
Mollion Helena,
Benatru Isabelle,
Broussolle Emmanuel
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20154
Subject(s) - tetrabenazine , modafinil , dyskinesia , vigilance (psychology) , tardive dyskinesia , medicine , dopaminergic , anesthesia , psychology , neuroscience , pharmacology , dopamine , psychiatry , parkinson's disease , schizophrenia (object oriented programming) , disease
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4‐month period. They were secondly dramatically improved by tetrabenazine, a presynaptic dopaminergic depleting drug which was introduced after the 4‐month adrafinil‐free period. © 2004 Movement Disorder Society