Premium
L ‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings
Author(s) -
Evans Andrew H.,
Costa Durval C.,
Gacinovic Sveto,
Katzenschlager Regina,
O'Sullivan John D.,
Heales Simon,
Lee Phillip,
Lees Andrew J.
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20146
Subject(s) - parkinsonism , dopamine transporter , putamen , dopamine receptor d2 , dopamine , context (archaeology) , dopamine plasma membrane transport proteins , endocrinology , medicine , spect imaging , dopamine receptor , psychology , neuroscience , chemistry , dopaminergic , nuclear medicine , biology , disease , paleontology
Reports of parkinsonism in phenylketonuria are exceedingly rare. We report on a patient who had received a delayed diagnosis of phenylketonuria as an infant and subsequently developed levodopa‐responsive parkinsonism at the age of 33. Single‐photon emission computed tomography (SPECT) using 123 I‐FP‐CIT ([ 123 )I]‐2 beta‐carbomethoxy‐3beta‐(‐4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane) used to measure dopamine transporter levels on two occasions, 7 and 9 years after the onset of neurological symptoms, were normal. Iodine‐123‐iodo‐lisuride SPECT (IBZM) imaging, however, showed reduced caudate over putamen binding. This combination of imaging findings indicates a possible upregulation of postsynaptic D2 receptors in the context of intact presynaptic dopamine nerve terminal density. © 2004 Movement Disorder Society
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom