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Tumor diagnosis preceding Parkinson's disease: A case–control study
Author(s) -
D'Amelio Marco,
Ragonese Paolo,
Morgante Letterio,
Epifanio Antonio,
Callari Graziella,
Salemi Giuseppe,
Savettieri Giovanni
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20123
Subject(s) - medicine , odds ratio , confidence interval , case control study , logistic regression , population , epidemiology , parkinson's disease , cancer , gastroenterology , disease , environmental health
Lower cancer risk in Parkinson's disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case–control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD‐free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine‐related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2–0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% CI, 0.1–0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% CI, 0.1–2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1–0.7). Still, risk was decreased for endocrine‐related tumors (adjusted OR, 0.3; 95% CI, 0.1–0.9) and non–endocrine‐related tumors (adjusted OR, 0.4; 95% CI, 0.1–0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies. © 2004 Movement Disorder Society