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Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease
Author(s) -
Bakker Maaike,
Esselink Rianne A.J.,
Munneke Marten,
LimousinDowsey Patricia,
Speelman Hans D.,
Bloem Bastiaan R.
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20116
Subject(s) - pallidotomy , subthalamic nucleus , deep brain stimulation , parkinson's disease , physical medicine and rehabilitation , globus pallidus , stereotactic surgery , medicine , gait , stimulation , dystonia , neurosurgery , movement disorders , neuroscience , psychology , basal ganglia , disease , surgery , central nervous system
Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta‐analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase. © 2004 Movement Disorder Society