Premium
Transdermal apomorphine permeation from microemulsions: A new treatment in Parkinson's disease
Author(s) -
Priano Lorenzo,
Albani Gianni,
Brioschi Andrea,
Calderoni Sara,
Lopiano Leonardo,
Rizzone Mario,
Cavalli Roberta,
Gasco Maria Rosa,
Scaglione Francesco,
Fraschini Franco,
Bergamasco Bruno,
Mauro Alessandro
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20054
Subject(s) - tolerability , levodopa , apomorphine , transdermal , parkinson's disease , medicine , pharmacology , rotigotine , drug , pharmacokinetics , dopamine , disease , dopaminergic , adverse effect
We studied absorption, efficacy, and tolerability in Parkinson's disease (PD) of a new preparation of apomorphine included in a microemulsion and administered by transdermal route (Apo‐MTD). Twenty‐one PD patients were treated with levodopa plus oral dopamine‐agonists (T0), with levodopa alone (T1), finally with levodopa plus Apo‐MTD (T2). Apo‐MTD provided therapeutic plasma levels for many hours, improved Unified Parkinson's Disease Rating Scale III scores, and reduced total duration of off periods compared to T0 and T1. We concluded that Apo‐MTD is absorbed and demonstrates clinical efficacy and long action. Therefore, it seems a promising add‐on treatment for uncontrolled prolonged off phases in PD patients, but chronic tolerability needs further study. © 2004 Movement Disorder Society