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Imaging of activated microglia with PET and [ 11 C]PK 11195 in corticobasal degeneration
Author(s) -
Henkel Karsten,
Karitzky Jochen,
Schmid Michaela,
Mader Irina,
Glatting Gerhard,
Unger Jürgen W.,
Neumaier Bernd,
Ludolph Albert C.,
Reske Sven N.,
Landwehrmeyer G. Bernhard
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20040
Subject(s) - corticobasal degeneration , microglia , neurodegeneration , basal ganglia , positron emission tomography , neuroscience , movement disorders , cortex (anatomy) , medicine , pathology , psychology , central nervous system , inflammation , progressive supranuclear palsy , atrophy , disease
Positron emission tomography (PET) using [ 11 C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left‐sided symptoms was studied using fluorodeoxyglucose (FDG) and [ 11 C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [ 11 C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. © 2004 Movement Disorder Society