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A consanguineous Turkish family with early‐onset Parkinson's disease and an exon 4 parkin deletion
Author(s) -
Dogu Okan,
Johnson Janel,
Hernandez Dena,
Hanson Melissa,
Hardy John,
Apaydin Hulya,
Özekmekçi Sibel,
Sevim Serhan,
GwinnHardy Katrina,
Singleton Andrew
Publication year - 2004
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.20028
Subject(s) - parkin , genetics , turkish , exon , parkinson's disease , degenerative disease , medicine , disease , consanguinity , biology , gene , philosophy , linguistics
The importance of parkin in early‐onset Parkinson's disease in Japan, Europe, and the United States is well established. The contribution of this gene to the risk of Parkinson's disease in other populations is less well known. To explore the importance of parkin in those of Turkish ancestry, we studied familial cases from that country, and identified a consanguineous family with early‐onset Parkinson's disease due to a homozygous mutation in parkin . © 2004 Movement Disorder Society