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Quality of life outcomes following surgical treatment of Parkinson's disease
Author(s) -
Gray Alastair,
McNamara Iain,
Aziz Tipu,
Gregory Ralph,
Bain Peter,
Wilson Joanna,
Scott Richard
Publication year - 2002
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.1259
Subject(s) - pallidotomy , thalamotomy , quality of life (healthcare) , parkinson's disease , medicine , rating scale , deep brain stimulation , physical therapy , disease , subthalamic nucleus , physical medicine and rehabilitation , surgery , psychology , nursing , developmental psychology
We assessed the impact of surgical treatment of Parkinson's disease on quality of life using generic quality of life instruments and utility scores. The Medical Outcomes Study short form health survey SF‐36 and Parkinson's Disease Questionnaire PDQ‐39 were used before and 3–6 months after surgery to assess quality of life, and the results were converted into utility valuations. Ninety‐seven patients were studied; 33 underwent unilateral thalamotomy, 33 unilateral pallidotomy, 20 bilateral pallidotomy, six subthalamic nucleus (STN) lesions, four mixed lesions, and in one case bilateral STN stimulation. All dimensions of the SF‐36 except role mental and mental health showed statistically significant improvement following surgery. The PDQ‐39 recorded significant improvements in the mobility, stigma , and bodily discomfort dimensions. The rating scale and time trade‐off scales showed statistically significant gains in utility of 8% and 3%, respectively. Gains were particularly marked in the bilateral pallidotomy group. Differences in patient characteristics and selection made direct comparisons between procedures unreliable. Quality of life in patients with advanced Parkinson's disease is amenable to measurement; such measurement provides tentative evidence of significant gains in quality of life following some neurosurgical procedures. © 2001 Movement Disorder Society.